Biochemical assays for Multiple Targets

  • Proven track record with kinases, phosphatases, proteases,lipid metabolic enzymes, epigenetic enzymes, ubiquitinautophagy and SUMO related enzymes,

  • Ligand/receptor, DNA/protein and protein/protein interaction

Focused library screens and hit confirmation

Support project in Hit to Lead (H2L) and Lead Optimization (LO) Phases

Testing of H2L and LO compounds

  • primary

  • secondary

  • selectivity/profiling assays

Support of Hit Validation

  • Development of compound binding assays, thermal shift or other binding assays

  • Studies of mechanism action for enzyme kinetics, compound reversibility